This can lead to decreased blood flow. High LDL cholesterol is associated with an increased risk of coronary artery disease. Most statins should be taken once every 24 hours. Depending on the particular medication and dosage, you may need to take your statin twice a day. Certain statins work better when taken with a meal.
This is because the cholesterol-making enzyme is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short. Simvastatin is an example of a statin that works better if taken in the evening.
Lovastatin should be taken with dinner. However, the extended-release version of lovastatin, Altoprev, should be taken at bedtime.
Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours. Follow directions carefully for maximum effectiveness. Your doctor knows your personal medical issues and is your best source for information. Doctors consider HDL cholesterol to be beneficial because it can transport other forms of cholesterol from the blood to the liver, which helps the body get rid of bad cholesterol.
It is important that a person taking statins follows the advice of their prescribing doctor regarding the time of day to take them.
The recommended time, which is something that a person should discuss with their doctor, will vary depending on the type of statin. A systematic review found that short-acting statins worked best when people took them in the evening.
The people who took these statins toward the end of the day had lower total cholesterol and LDL cholesterol levels compared with the people who took them in the morning. Another review came to the same conclusion. Short-acting statins work better at night because the liver enzyme that produces cholesterol is more active at this time. Most short-acting statins have a half-life of 6 hours. It takes longer for the body to process long-acting statins, which may have a half-life of up to 19 hours.
The two reviews above noted that long-acting statins worked equally well whether a person took them in the morning or the evening. Therefore, people taking long-acting statins can choose which time of the day best suits them. The authors recommend that people using long-acting statins take them at a time of day that is easy for them to remember. It is important to be consistent with the timing of doses, so if a person prefers to take statins in the morning, they should take them in the morning every day.
People who are taking statins may need to take them indefinitely. In many cases, when a person stops taking statins, their cholesterol levels increase again. Some people might be able to stop taking statins or reduce their dosage if they significantly lower their risk of heart disease.
A person may do this by losing a significant amount of weight, quitting smoking , or making other major lifestyle changes that improve their health. Even in these cases though, a person should talk to a doctor before they stop taking statins or any other medications. Statins come in a range of types and dosages. A person can discuss with their doctor which type of statin may work best for them. If a person has an increased risk of heart disease, their doctor may prescribe a higher dosage or a long-acting statin.
Conversely, a person with less risk of heart disease may start on a lower dosage or a short-acting statin. Recent evidence suggests that many people can benefit from taking statins, even if they do not have high blood cholesterol levels.
Endogenous cholesterol synthesis is cyclical in nature with the greatest production during fasting states. To maximize the effects of statins with a short half-life, fluvastatin, lovastatin, and simvastatin should be dosed at bedtime allowing the greatest drug concentration to be present during peak endogenous cholesterol synthesis. The long half-life of atorvastatin, pitavastatin, pravastatin, and rosuvastatin allows for flexibility in administration time. Author: Carolyn J.
Hydroxymethylglutaryl coenzyme A HMG-CoA reductase inhibitors, more commonly known as statins, are recommended as first-line agents in the reduction of low-density lipoprotein cholesterol LDL-C. There is known morbidity and mortality benefit associated with LDL-C reduction from statin therapy; therefore, it is vital that patients take the medication in a way that provides the greatest effect.
Although some cholesterol comes from dietary intake, a significant amount is produced endogenously. It was previously hypothesized that human cholesterol production may be cyclical in nature mimicking the confirmed pattern of cholesterol synthesis in animals.
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