Weight gain is one of the potential side effects of antidepressant use, with some sources estimating that 25 percent of people using antidepressants experience an increase in weight. Although the reactions to specific antidepressants vary between individuals, some antidepressant medications are more likely to lead to weight gain than others.
Experts do not fully understand why antidepressants lead to weight gain in some people. One theory is that both metabolism and hunger levels may be affected. Also, depression itself may cause weight gain in some people and weight loss in others. Antidepressants interfere with serotonin , the neurotransmitter that regulates anxiety and mood while also controlling appetite.
In particular, these changes may increase cravings for carbohydrate-rich foods, such as bread, pasta, and desserts. When people are depressed, their appetites are affected. In some people, this may make them hungrier while others lose their appetite. It should also be noted that depression can lead to fatigue and inactivity, and a lack of physical activity can cause weight gain. If a person is experiencing weight gain while taking antidepressants, it may be an indication that the medication is not combatting their depression effectively.
Also known as cyclic antidepressants, TCAs are some of the earliest forms of antidepressant medications. They are not as commonly prescribed as more modern forms of antidepressants, as they can cause more side effects, including weight gain. Older research suggests that excessive weight gain caused many users to quit TCA treatment.
However, cyclic antidepressants can be effective, especially for some people who do not respond to other treatments. MAOIs are another early class of antidepressants and have generally been replaced by newer antidepressant drugs. Although effective, they tend to cause weight gain and several other adverse reactions.
In addition, people who take MAOIs may need to restrict their diets, as these drugs can cause elevated blood pressure levels when taken with some foods and medications. However, MAOIs help relieve depression in some people who do not see improvements with other drugs. One type of MAOI called selegiline Emsam , a topical treatment that is applied to the skin as a patch, has been associated with weight loss in some users. The most commonly prescribed form of antidepressant medication, selective serotonin reuptake inhibitors SSRIs have been associated with weight loss in short-term use, but may cause weight gain when used long term.
However, weight gain associated with SSRIs depends on the length of time they are taken, as well as the type. For example, paroxetine is the most likely to lead to weight gain, while sertraline is least likely. Visit her blog or Instagram. If your doctor prescribed you an antidepressant, these drugs can have many benefits on your mental health. But that won't stop you from worrying about…. Patients at peak risk years after taking the drugs.
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